We collaborate with our neurosurgeons, geneticists, and laboratory medicine specialists to operate a CSF biorepository at Children's National Hospital (currently called "Bear Brain Bank" ... while we wait for an interested donor 😉).
Our first project builds on our previous findings that blood products induce neuroinflammation following TBI. Would this pathophysiology carry over to another brain pathology with gross CNS hemorrhage: Post-hemorrhagic Hydrocephalus (PHH)? Using our center's banked CSF samples, we aim to characterize the neuroinflammatory signature in patients with PHH and determine (1) how it contributes to and/or predicts clinical outcomes and (2) whether it may present a therapeutic target.
An animal research component is in the works ...
Our first project builds on our previous findings that blood products induce neuroinflammation following TBI. Would this pathophysiology carry over to another brain pathology with gross CNS hemorrhage: Post-hemorrhagic Hydrocephalus (PHH)? Using our center's banked CSF samples, we aim to characterize the neuroinflammatory signature in patients with PHH and determine (1) how it contributes to and/or predicts clinical outcomes and (2) whether it may present a therapeutic target.
An animal research component is in the works ...
CSF Biobank Team:
Daniel Donoho (co-director)
Akilah Pascall
Jamie Fraser
William Suslovic
Meghan Delaney
... and many more
CNH Collaborators:
The Developing Brain Institute
Zickler Family Prenatal Pediatrics Institute
Remote Collaborators:
The Akassoglou Lab
The Mendiola Lab
Daniel Donoho (co-director)
Akilah Pascall
Jamie Fraser
William Suslovic
Meghan Delaney
... and many more
CNH Collaborators:
The Developing Brain Institute
Zickler Family Prenatal Pediatrics Institute
Remote Collaborators:
The Akassoglou Lab
The Mendiola Lab